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c/semaglutide·submitted 9 days ago by u/helga_vermeulen

[PSA] 0.25 for four weeks is not a suggestion, it is the whole plan

PSAbranch of 8 comments

0.25 for four weeks is not a suggestion, it is the whole plan. Two minutes of reading now saves an argument later. reflux made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it. What I would tell week-one me, in order of how much time it would have…

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8 comments, started 8 days ago
u/slow_logbook_notes83 points·8 days ago

What did week 40 look like compared with this one? The month either side is the useful comparison.

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u/plain_titration-36 points·7 days ago·edited

Genuine question — is the appetite effect still there, or is it just the scale that has paused?

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u/helga_vermeulenOP1 point·7 days ago

That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.

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u/joaquin_stanescu29 points·7 days ago

Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.

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u/ffmi_watcher37 points·7 days ago

This matches me almost exactly, right down to the food noise showing up on the second day and being gone by the fourth.

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u/ismael_chukwu27 points·7 days ago

Same injection day each week, or has it drifted?

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u/lane_map_larrylogistics37 points·7 days ago

The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.

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u/stubborn_batchlist_only30 points·7 days ago

Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.

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