the titration question that gets asked weekly, answered properly
the titration question that gets asked weekly, answered properly. Making the case below, and I expect to lose some of it in the comments. The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does. Steady state after a dose change…
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Flairing this as a check-in rather than a question, since that is what it turned into.
week 48 plateau is the most predictable thing in this entire board
Yes. Week 6 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the constipation usually fades at a stable dose.
the food noise going quiet is the effect people actually describe
nausea that arrives on day two and fades by day four is the standard shape