the titration question that gets asked weekly, answered properly
the titration question that gets asked weekly, answered properly. Making the case below, and I expect to lose some of it in the comments. The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does. Steady state after a dose change…
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
Cosigning.
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
This matches me almost exactly, right down to the muscle cramps showing up on the second day and being gone by the fourth.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
That figure is the 68-week trial mean, not a weekly rate.
yara_boateng is describing the standard shape here and it matches the trial data better than most anecdotes do.
Cosigning.
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
stalling at 0.25mg is information, not a verdict
protein first, then everything else gets easier