small win: titration stopped being a problem at week 58
small win: titration stopped being a problem at week 58. Full detail below, and I have tried to keep the editorialising out of it. Sat at 1.0mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the nausea. Kept a log from week one and the…
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
iman_castellanos is describing the standard shape here and it matches the trial data better than most anecdotes do.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
protein first, then everything else gets easier
Genuine question — is the appetite effect still there, or is it just the scale that has paused?
Genuine question — is the appetite effect still there, or is it just the scale that has paused?
Disagree with this specific line. A pause at 0.25mg is not evidence that 0.25mg has stopped working.
Genuine question — is the appetite effect still there, or is it just the scale that has paused?
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.