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c/semaglutide·posted 1 year ago by u/oskar_kaufmann

switched from 0.5mg to 1.0mg and muscle cramps got better, not worse

Question Well Actually ×6 Cold Box ×1

Something I keep coming back to: switched from 0.5mg to 1.0mg and muscle cramps got better, not worse.

Since the title puts numbers in the shop window: 0.5mg and 1.0mg.

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

Would rather be corrected in public than confident in private.

3,067 up / 506 down86% upvoted27 commentsid 1aza3y11 Jan 2025

27 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/zofia_lindholm293 points·1 year ago

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

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u/ines_castellanos105 points·1 year ago

My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.

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u/arne_amankwah305 points·1 year ago

staying at 0.5mg for an extra month is a legitimate plan

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u/dose_creep_dan74 points·1 year ago

the food noise going quiet is the effect people actually describe

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u/helga_vermeulen20 points·1 year ago

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

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u/ines_castellanos189 points·1 year ago

Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.

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u/careful_gradient_again46 points·1 year ago

sema is weekly for a reason, the half-life does the smoothing

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u/oskar_kaufmann37 points·1 year ago

the first four weeks are a tolerance check, not a weight-loss phase

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u/niels_lindqvist65 points·1 year ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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