small win: plateau stopped being a problem at week 28
small win: plateau stopped being a problem at week 28. Numbers below. Ask me the boring questions, they are the useful ones.
Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
Tell me where this is wrong. That is the useful part of posting it.
best — the order this archive was captured in
Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.
do not chase somebody else’s titration schedule, they are not you
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the first four weeks are a tolerance check, not a weight-loss phase
STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
dose day drift of a day either way is fine, the curve barely notices
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the nausea usually fades at a stable dose.
food noise made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
Did protein intake change in the same window?
Did protein intake change in the same window?
greta_lokken is describing the standard shape here and it matches the trial data better than most anecdotes do.
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
Same. I sat at 1.7mg for three months because it was working and there was nothing to fix.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
This matches me almost exactly, right down to the injection-site soreness showing up on the second day and being gone by the fourth.
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
Disagree.
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
What dose and how many weeks at it before this started?
Does food noise track the day after the shot, or is it there all week?
Strongly agree on protein. It did more for my food noise than any of the things I bought to fix my food noise.
Yes. Week 58 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
Agreed, and the bit people skip is that the ladder is a tolerance ladder. It is not a potency ranking.
if 2.4mg is working there is no prize for going up
if 2.4mg is working there is no prize for going up
Disagree with this specific line. A pause at 2.4mg is not evidence that 2.4mg has stopped working.
- 1The appetite thing was the surprise. I expected to feel full. What I got was…7 comments in this branch · started by u/diego_sorensen
- 2Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up…7 comments in this branch · started by u/dead_space_doug