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c/semaglutide·posted 2 years ago by u/rafael_ostergaard

[Question] semaglutide — what am I missing here

Question Well Actually ×6 Clean Column ×1 Receipts ×1

semaglutide — what am I missing here, and I want the answer with the reasoning attached rather than just the conclusion.

My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

Week 22: 7kg down, sulphur burps basically gone since about week 7, and the honest headline is that nothing dramatic happened. It was boring and it worked.

That is everything I have. The rest is opinion and I have tried to keep it out.

9,467 up / 483 down95% upvoted27 commentsid 12f8k529 Apr 2024

27 comments

12 in this archive, depth 6

best — the order this archive was captured in

u/anya_antonsen1.5k points·2 years ago

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

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u/titration_marshalMOD1.1k points·2 years ago

Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.

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u/vikram_ferreira0 points·2 years ago

Leaving this up.

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

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u/marit_coelho1 point·2 years ago

Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.

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u/oskar_ibarra-2 points·2 years ago·edited

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

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u/rafael_ostergaardOP0 points·2 years ago

Are you measuring anything other than weight? Waist is usually the one that keeps moving.

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u/niels_lindqvist1 point·2 years ago

Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.

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u/ferritin_low560 points·2 years ago

the scale is the least sensitive instrument you own

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u/viktor_nkemelu332 points·2 years ago

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

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u/iman_falk502 points·2 years ago

do not chase somebody else’s titration schedule, they are not you

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u/arne_amankwah386 points·2 years ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/osman_ferrari73 points·2 years ago

nausea that arrives on day two and fades by day four is the standard shape

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