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317

switched from 5mg to 12.5mg and food noise got better, not worse

Meta Cold Box ×2

switched from 5mg to 12.5mg and food noise got better, not worse. I have gone back and forth on this for months.

The relevant figures are 5mg and 12.5mg, and they come from the same log I have kept the whole time.

Drifted up 12kg over a winter and panicked. It came back off without any change, which is apparently just what weight does.

Weigh monthly now. Best change I made in the whole run and it cost nothing.

Happy to answer the boring questions. Those are usually the ones worth asking.

451 up / 134 down77% upvoted25 commentsid orvxwc4 May 2025

25 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/nhs_waitlist_nUK35 points·1 year ago

Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lowers average exposure. That is why appetite return is often the first thing noticed.

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u/bastian_aalto-20 points·1 year ago

That reads like a taper schedule and this board cannot hand those out.

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u/neha_falk21 points·1 year ago·edited

Wrote down what maintenance would look like at about week 55, before I needed it. Having decided in advance made the transition boring.

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u/mod_cold_roommod · c/coldchain16 points·1 year ago

What maintenance actually looks like, from the people on this board who have been in it longest.

You find a dose or an interval that holds the weight with side effects you barely notice, and then you stop optimising. Weigh monthly rather than daily. Expect a couple of kilos of range and do not act on it. Keep the habits that did the work in the losing phase, because they are the part that has to outlive the dose.

The most common mistake described here is treating arrival as a plateau and pushing the dose to chase a number chosen at week one by a person who did not yet know what maintenance felt like.

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u/maintenance_mode_maxmaintenance5 points·1 year ago

find the dose that holds, then stop optimising

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[removed]4 points·1 year ago

[removed by moderator]

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u/still_here_2026MOD12 points·1 year ago

Standing reminder that regain after stopping is a documented pharmacological outcome, and posts framing it as a moral failure get edited.

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u/priya_weiss3 points·1 year ago

regain after stopping is the expected outcome, not a personal failure

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u/andres_dahlberg8 points·1 year ago

Body weight varies by a couple of kilos over days in stable people through fluid, glycogen and gut content. A range is not a trend.

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u/usp_appendixcompendial5 points·1 year ago

What dose are you holding, and for how long now?

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u/teodor_duarteOP4 points·1 year ago

do not chase the last two kilos with a dose increase

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u/paper_trail_paulavetting10 points·1 year ago

On stopping, since it is the question underneath most posts here.

Withdrawal studies in this class show substantial regain after discontinuation, consistently, across compounds. Appetite returns first, typically well before the scale moves. That is a statement about the pharmacology of a chronic condition, not about anybody’s character, and the framing matters because people quit in shame over an entirely predictable result.

If you are going to stop — for cost, for supply, for any reason — the useful preparation is deciding in advance what you will watch for and what your plan is when appetite comes back. Doing that in advance is much easier than doing it in a panic, and it is a conversation to have with someone who knows your history.

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u/adnan_sandvik6 points·1 year ago

Has appetite changed, or only the scale?

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u/aleksi_lehtinen5 points·1 year ago

Two years at maintenance. The logistics are the only remaining work — ordering, storing, remembering.

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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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