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391

switched from 7.5mg to 10mg and injection-site soreness got better, not worse

Discussion The Quiet One ×3

switched from 7.5mg to 10mg and injection-site soreness got better, not worse. Making the case below, and I expect to lose some of it in the comments.

Pulling the figures out of the title: 7.5mg and 10mg. All of it is written down as it happened rather than reconstructed.

Been at maintenance for 16 months on 1.0mg. Nothing happens. That is the whole report and it took me a while to accept it as success.

Appetite returning before the scale moves follows from the mechanism: the appetite effect is the proximal one and weight is the lagging integrated outcome.

Happy to answer the boring questions. Those are usually the ones worth asking.

560 up / 169 down77% upvoted22 commentsid 1rbcr412 Jun 2024

22 comments

19 in this archive, depth 5

best — the order this archive was captured in

u/osman_ferrari64 points·2 years ago

Body weight varies by a couple of kilos over days in stable people through fluid, glycogen and gut content. A range is not a trend.

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u/kaplan_meier_kim22 points·2 years ago

find the dose that holds, then stop optimising

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u/ferritin_low-26 points·2 years ago

Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s discipline.

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u/nikhil_lindqvist1 point·2 years ago

appetite returns before the scale acknowledges anything

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u/cold_chromatogram_onlyOP1 point·2 years ago

What is the plan if the drift continues for another month?

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u/nnt_nate1 point·2 years ago

What is the plan if the drift continues for another month?

Disagreeing with this bit: a two-kilo range is not drift and treating it as a problem creates one.

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u/cold_chromatogram_onlyOP1 point·2 years ago

Small fix — you have described interval stretching and called it a dose reduction. The exposure profiles differ.

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u/usp_appendixcompendial1 point·2 years ago

the trials that looked at withdrawal are unambiguous about what follows

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u/nabila_espinoza1 point·2 years ago

Withdrawal studies in this class consistently show substantial regain after discontinuation.

Adding one thing — decide what maintenance looks like before you arrive at it.

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u/priya_weiss59 points·2 years ago

Maintenance is the phase with the least published guidance and the most individual variation, which is precisely why board consensus here is worth less than usual.

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u/rafael_krastev25 points·2 years ago

Not convinced. Interval stretching changes your exposure profile, not just the total, and the two are not equivalent.

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[deleted]10 points·2 years ago

[deleted]

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u/cold_chromatogram_onlyOP4 points·2 years ago

What does your weigh-in frequency look like at this point?

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u/nhs_waitlist_nUK2 points·2 years ago

a few kilos of drift is not a relapse

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u/nadia_nascimento25 points·2 years ago

I would not treat a two-kilo range as drift requiring action. That is ordinary weight variation.

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u/enzo_danquah10 points·2 years ago

Same. Monthly is plenty at this stage and daily weighing made me miserable for no information gain.

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u/ilias_nakamura30 points·2 years ago

regain after stopping is the expected outcome, not a personal failure

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u/vitamin_d_void12 points·2 years ago

Yes — interval stretching and dose reduction are different levers and people use the words interchangeably.

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u/yara_antonsen30 points·2 years ago

That reads like a taper schedule and this board cannot hand those out.

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The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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