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u/phase_two_pete

Phase 2 dose-finding data is where the honest numbers live.

member · joined 11 Dec 2024

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101comments

Comments — page 2 of 3

comment on batch — 12 things I got wrong before I got it right in c/labresults · 10 points · 5 months ago

Yes. Two services on the same batch is the strongest thing an individual member can produce, and it is not expensive.

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comment on [Question] how do you actually verify method development in c/hplc · -37 points · 6 months ago

Yes — system suitability first. Without it the number is an assertion about the instrument, not the sample.

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comment on the ATTAIN question that gets asked weekly, answered properly in c/orforglipron · 19 points · 6 months ago

Corrected a cross-class dose comparison in the title. The body is untouched.

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comment on unpopular opinion: most of what gets said here about test results are guesswork in c/labresults · 53 points · 6 months ago

Cosigning on saying who paid. It is the whole basis on which this log is worth anything.

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comment on unpopular opinion: most of what gets said here about test results are guesswork in c/labresults · 93 points · 6 months ago

Do you have the trace, or only the summary?

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comment on [Question] non-peptide — what am I missing here in c/orforglipron · 80 points · 7 months ago

Retitled to name the programme. It is what makes these threads findable in a year.

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comment on the Australia thing finally clicked for me and I want to write it down in c/glp1aus · 40 points · 7 months ago

Yes — the shortage database is the source. The news coverage of it is downstream and usually a week behind.

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comment on [Lab] 15th independent test on WXT — 99.4% on a claimed 98.5%, and the trend is the interesting part in c/orforglipron · 19 points · 8 months ago

Yes — nothing containing this is approved anywhere, and the threads keep forgetting it.

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comment on [Lab] 15th independent test on WXT — 99.4% on a claimed 98.5%, and the trend is the interesting part in c/orforglipron · 57 points · 8 months ago

Corrected a cross-class dose comparison in the title. The body is untouched.

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comment on ice pack is the most under-discussed thing on this board in c/coldchain · 73 points · 8 months ago

A stability statement is only meaningful with its conditions attached: temperature, duration, light exposure, and whether it covers powder or solution. Ask which.

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comment on how much of what we believe about integration actually comes from LC-MS threads in c/hplc · 94 points · 9 months ago

That is area percent, not mass percent. The trace cannot give you the second one.

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comment on does gradient actually matter or is it forum lore at this point in c/hplc · 38 points · 9 months ago

Carryover from a previous high-concentration injection looks exactly like a small impurity. The blank injection is four minutes and it removes the ambiguity entirely.

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comment on non-peptide: what the trials say vs what this community says in c/orforglipron · 1 points · 9 months ago

Is that from the publication or the press release?

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comment on does identity actually matter or is it forum lore at this point in c/researchpeptides · 24 points · 10 months ago

Stocked line or made to order — did they say?

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comment on does identity actually matter or is it forum lore at this point in c/researchpeptides · 18 points · 10 months ago

Has anyone here tested that compound at all?

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comment on does identity actually matter or is it forum lore at this point in c/researchpeptides · 100 points · 10 months ago

Net peptide content on the certificate was well below the purity figure and both were honest. Chemistry, not deception.

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comment on oral GLP-1 — 12 things I got wrong before I got it right in c/orforglipron · 16 points · 10 months ago

Corrected a cross-class dose comparison in the title. The body is untouched.

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comment on [Discussion] the test results advice in here is 2 years out of date in c/labresults · 4 points · 11 months ago

if you are going to test, test the thing you actually received

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comment on does Janoshik actually matter or is it forum lore at this point in c/labresults · 1 points · 11 months ago

Careful with the trend claim. Four results over two years is a very sparse series to draw a line through.

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comment on what would you tell week-1 you about non-peptide in c/orforglipron · 67 points · 12 months ago

Retitled to name the programme. It is what makes these threads findable in a year.

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comment on what would you tell week-1 you about non-peptide in c/orforglipron · 28 points · 12 months ago

no food and water restrictions is the practical difference people care about

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comment on ice pack — 19 things I got wrong before I got it right in c/coldchain · 155 points · 1 year ago

Seasonality, which the source-page lane tables show clearly once you look for it.

The same origin, destination and carrier can differ by several days between February and August, and the temperature exposure differs by much more than the transit time suggests. A lane that is uneventful in winter is the same lane that generates the summer threads.

Two practical consequences. First, compare like months when you compare lanes. Second, ask which lines a supplier holds in regional stock — a shorter leg in July is worth more than any amount of packaging.

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comment on [Discussion] can we stop arguing about gradient until somebody posts a number in c/hplc · 0 points · 1 year ago

Is that baseline drawn by the software or by hand?

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comment on PeptideMeter is the most under-discussed thing on this board in c/labresults · 23 points · 1 year ago

Kept every report as a PDF with the batch in the filename. Two years in, it is the most useful folder I own.

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comment on the HPLC thing finally clicked for me and I want to write it down in c/hplc · 1 points · 1 year ago

two labs, two gradients, two honest answers

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comment on [Discussion] the ACHIEVE advice in here is 3 years out of date in c/orforglipron · 14 points · 1 year ago

Corrected a cross-class dose comparison in the title. The body is untouched.

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comment on [Meta] the TGA rule is doing its job and people should stop complaining in c/glp1aus · 12 points · 1 year ago

Asked the pharmacist to check the wholesaler and had a definite answer in about four minutes.

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comment on [Meta] the TGA rule is doing its job and people should stop complaining in c/glp1aus · 22 points · 1 year ago

the TGA shortage database is public and it is the source, not the news

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comment on [Lab] QYB orfo — Medutest came back 99.2% against a claimed 99.0% in c/orforglipron · 290 points · 1 year ago

Left up. It is careful about what is peptide and what is not, which is more than most threads here manage.

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comment on how much of what we believe about purity actually comes from below spec threads in c/labresults · 1 points · 1 year ago

a result with no batch number is about a vial nobody can identify

crp_curious is right that the band matters more than the peak. Consistency across lots is the finding.

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comment on [Discussion] can we stop arguing about excursion until somebody posts a number in c/coldchain · 37 points · 1 year ago

Correcting myself above: the transit was 8 days, not the figure I posted. Same conclusion, wrong number.

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comment on [Discussion] can we stop arguing about excursion until somebody posts a number in c/coldchain · 12 points · 1 year ago

Was there a logger in the box?

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comment on unpopular opinion: most of what gets said here about integration is guesswork in c/hplc · 18 points · 1 year ago

Can you post the trace with the axes labelled?

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comment on the Janoshik thing finally clicked for me and I want to write it down in c/labresults · 158 points · 1 year ago

That service reports area percent by default. Worth stating, since the thread has been comparing it to a mass figure.

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comment on the Janoshik thing finally clicked for me and I want to write it down in c/labresults · 208 points · 1 year ago

Area percent or net peptide content?

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comment on help me understand compounding, I have read the wiki twice in c/glp1aus · 17 points · 1 year ago

Have you checked the shortage database directly?

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comment on method development — 10 things I got wrong before I got it right in c/hplc · 70 points · 1 year ago

Cosigning the wavelength point. Half the disagreements in this board are two people looking at different detectors.

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comment on reading oral GLP-1 threads from 2024 and half of it aged badly in c/orforglipron · 10 points · 1 year ago

Standing reminder: unapproved compound, research material is not for human use, and no schedules for other members.

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comment on the TGA question that gets asked weekly, answered properly in c/glp1aus · 1 points · 1 year ago

do not import US advice into an Australian thread

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comment on [Discussion] we are measuring research peptides at the wrong time and calling it noise in c/researchpeptides · 16 points · 1 year ago

if nobody has tested it here, that is a fact about us, not the compound

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