u/phase_two_pete
Phase 2 dose-finding data is where the honest numbers live.
member · joined 11 Dec 2024
Comments — page 3 of 3
comment on cold chain — 23 things I got wrong before I got it right in c/coldchain · 164 points · 2 years ago
Yes — reconstitution date on the vial. It is the number you will want and cannot reconstruct.
comment on [Question] New Zealand — has anyone got a straight answer on lyophilised in c/coldchain · 6 points · 2 years ago
This. A liquid gel pack on arrival tells you about the pack’s duty cycle, not about the vial.
comment on help me understand method development, I have read the wiki twice in c/hplc · 30 points · 2 years ago
Ran a blank after a high-concentration injection and found the carryover I had been calling an impurity.
comment on [PSA] New Zealand is not what most of this community thinks it is in c/glp1aus · 59 points · 2 years ago
do not import US advice into an Australian thread
comment on [Discussion] the below spec advice in here is 2 years out of date in c/labresults · 48 points · 2 years ago
A series across separate lots estimates a process. Repeat tests on one lot estimate the measurement. Both are useful and they answer different questions.
comment on the stability question that gets asked weekly, answered properly in c/coldchain · 2 points · 2 years ago
That is the ambient temperature at the destination, not the temperature inside the box. The logger measures the second one.
comment on the stability question that gets asked weekly, answered properly in c/coldchain · 2 points · 2 years ago
Small fix — refrigerated, not frozen, once it is in solution.
comment on the stability question that gets asked weekly, answered properly in c/coldchain · 7 points · 2 years ago
Correcting myself above: the transit was 3 days, not the figure I posted. Same conclusion, wrong number.
comment on [Lab] 6th independent test on SWB — 99.1% on a claimed 99.0%, and the trend is the interesting part in c/orforglipron · 1 points · 2 years ago
Agreed that phase 3 is where the comparison becomes fair. Everything before it is inference.
comment on [Lab] 6th independent test on SWB — 99.1% on a claimed 99.0%, and the trend is the interesting part in c/orforglipron · -19 points · 2 years ago
Milligram-for-milligram comparison with an injectable peptide is not meaningful and I should not have made it.
comment on [Question] thymosin — what am I missing here in c/researchpeptides · 47 points · 2 years ago
Same. Net peptide content is where the difference between the label and the vial actually shows up.
comment on unpopular opinion: most of what gets said here about TGA is guesswork in c/glp1aus · 22 points · 2 years ago
say which state only if it matters, but always say which country
comment on [Question] how do you actually verify thymosin in c/researchpeptides · 206 points · 2 years ago
That result is an area percent from an unspecified method, which is not the same as the identity confirmation being discussed.
comment on [Lab] KP cagri — VendorInvestigate came back 98.1% against a claimed 97.5% in c/hplc · 73 points · 2 years ago
Small fix — 214nm, not 210. It matters for the comparison you are making with the other run.
comment on [Lab] QYB orfo — Medutest came back 99.3% against a claimed 99.0% in c/orforglipron · 32 points · 2 years ago
Left up. It is careful about what is peptide and what is not, which is more than most threads here manage.
comment on [Lab] split one vial across PeptideMeter and VendorInvestigate — 93.7% and 94.2% in c/hplc · 443 points · 2 years ago
Resolution between two peaks depends on retention, selectivity and efficiency. A shallower gradient buys retention and usually resolution, at the cost of peak width and run time.
comment on [Lab] 18th independent test on SWB — 99.4% on a claimed 99.0%, and the trend is the interesting part in c/hplc · 1 points · 2 years ago
report the method or do not report the number
comment on [Lab] 18th independent test on SWB — 99.4% on a claimed 99.0%, and the trend is the interesting part in c/hplc · 741 points · 2 years ago
Ran a blank after a high-concentration injection and found the carryover I had been calling an impurity.
comment on integration — 17 things I got wrong before I got it right in c/hplc · 2 points · 2 years ago
That figure cannot be quoted to two decimals off that baseline. The precision is not in the data.
comment on [PSA] test results are not what most of this community thinks it is in c/labresults · 69 points · 2 years ago
Sent a vial in specifically to check a supplier’s claim after a good experience. It matched. Boring result, worth logging.
comment on gradient — 17 things I got wrong before I got it right in c/hplc · 8 points · 2 years ago
Same view — reporting the gradient is what makes a result checkable rather than merely stated.