u/hassan_nilsen

buy small first is the lesson that keeps being learned expensively

the same token exists on several chains and they are not interchangeable

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

a payment sent on the wrong network is usually gone

Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.

Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.

Adding the standing caveat: none of this is approved anywhere and research material is not for human use.

It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.

hold the dose that works, the ladder is not a leaderboard

That is body weight change, not fat mass.

tired_ledger_notes is right about the escalation being the variable. It explains most of the difficult reports here.

Small fix — the figure you quoted is the claimed purity from the certificate, and the independent result was the higher of the two.

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

the wider-market names in the table are there because nobody has enough data on them

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

Small correction — the shop in that story has no independent testing on file at all, which is different from having a bad record.

Kept a log specifically because there is so little published. It is one person and it is not data.

Left up.

Adding the thing that would have caught it earliest — buy small and test before committing.

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.

Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.

Asked WXT for the batch record on a Tuesday and had the full document, batch and method line, before the end of the day. That is the bar now.

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

nothing here is available as a prescription product, so read every thread with that in mind

Yes, and the reason the wider-market table has no scores is that a score built on two reports would be a lie with a decimal point.

three independent results beat thirty forum posts

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

Do you have the transaction hash?

Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.

Right, and confirmations are the status. "Sent" means nothing until the chain agrees.

Are you being harder on yourself than you would be on somebody else posting this?

Kept a spreadsheet of quoted versus actual lead time across 8 orders. The quoted number held.

Chased the scale instead of the measurements for a year and made myself miserable for no additional progress.

Pasted rather than typed the address, then checked the first and last six characters. Habit now.

Did you come to this from sema, and if so how long was the gap?

Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.

Agreed, and the framing that helps is: this is a phase 2 compound with phase 3 running. Everything else is inference.

22kg over 59 weeks, never went past 10mg, and food noise stayed mild the whole way. Posting because the loud threads are all 15mg.

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

SURMOUNT-1 landed around 21% at 72 weeks on the top arm

Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.