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c/tirzepatide·posted 10 months ago by u/bastian_ekstrom

how much of what we believe about tirzepatide actually comes from 15mg threads

Trial Data Clean Column ×5 Cold Box ×1 Slow Clap ×1

how much of what we believe about tirzepatide actually comes from 15mg threads. If this has been answered properly somewhere, link me and I will delete.

15mg — those are the numbers, and they are the ones I am willing to defend.

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

I will update this if the picture changes rather than quietly leaving it up.

4,749 up / 661 down88% upvoted40 commentsid ooxhuk26 Sep 2025

40 comments

17 in this archive, depth 5

best — the order this archive was captured in

u/titration_marshalMOD853 points·10 months ago

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

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u/bastian_ekstromOP483 points·10 months ago

What step are you on and how long have you been there?

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u/hassan_nilsen-21 points·10 months ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/tidy_vialdrawer_pls628 points·10 months ago

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

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u/bastian_ekstromOP426 points·10 months ago

Are you comparing yourself with the trial mean or with the people who post the most?

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u/copay_card_cc127 points·10 months ago

the four-week step schedule is the label, not folklore

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u/ewan_marchand105 points·10 months ago

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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u/sofia_nascimento93 points·10 months ago

Which week did the appetite change actually land for you?

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u/discount_math_dm422 points·10 months ago

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

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u/tarek_kirchner229 points·10 months ago

Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.

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u/line_petrov415 points·10 months ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/ingrid_correia133 points·10 months ago

Week 78 was the first time the scale moved after a five-week stall. I changed nothing in that window.

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u/rania_marchand103 points·10 months ago

Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.

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u/fatima_wojcik86 points·10 months ago

Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.

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u/mod_cold_roommod · c/coldchain35 points·10 months ago

sulphur burps are the signature complaint and they are not dangerous

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u/adnan_nascimento174 points·10 months ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/halima_boateng175 points·10 months ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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