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u/bruno_dumitru

Contributes reviews on supplier material. Based in Angers.

member · joined 14 May 2025

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Comments — page 3 of 3

comment on [Vendor] BCH order #16 — Germany, 4 days, no drama, receipts inside in c/coldchain · 16 points · 1 year ago

I would not freeze it in solution. That is a different failure mode and a worse one.

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comment on someone explain insulin syringe to me like I have not read a paper in years in c/reconstitution · 26 points · 1 year ago

Disagree with the "more water is safer" framing. It is not safer, it is just a different number to divide by.

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comment on [Discussion] can we stop arguing about reconstitution until somebody posts a number in c/reconstitution · 1 points · 1 year ago

twice as much water halves the concentration and doubles the units for the same dose

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comment on [Question] mg/mL — what am I missing here in c/reconstitution · 57 points · 1 year ago

What concentration did you actually reconstitute at, rather than what did you intend to?

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comment on [Question] how do you actually verify gas fees in c/cryptopay · 6 points · 1 year ago

Confirmations are the count of blocks built on top of the one containing your transaction. Until there are some, the transaction is not settled in any meaningful sense.

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comment on [Question] how do you actually verify USDC in c/cryptopay · 6 points · 1 year ago

escrow arrangements are rare and worth asking about

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comment on the pharmacy question that gets asked weekly, answered properly in c/glp1eu · 249 points · 1 year ago

Yes. Pack sizes differ enough that per-month price comparisons across borders need to be normalised before they mean anything.

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comment on [Meta] the 503B rule is doing its job and people should stop complaining in c/compounding · 33 points · 1 year ago

the pharmacy and the prescriber are two separate questions

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comment on [Meta] the 503B rule is doing its job and people should stop complaining in c/compounding · 27 points · 1 year ago

the shortage list is the whole legal hinge and people skip it

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comment on reading BPC-157 threads from 2024 and half of it aged badly in c/bpc157 · 129 points · 1 year ago

It is a fifteen-residue peptide with a published sequence, which makes synthesis straightforward and makes identity verification the meaningful test rather than an optional extra.

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comment on reading BPC-157 threads from 2024 and half of it aged badly in c/bpc157 · 81 points · 1 year ago

pentadecapeptide, fifteen residues, and the sequence is public

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comment on [Question] New Zealand — has anyone got a straight answer on lyophilised in c/coldchain · 17 points · 2 years ago

Split an order across two months deliberately to compare summer and winter transit on the same lane.

plain_titration_2024 is right that the pack failing is not the material failing. Two separate claims.

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comment on [Vendor] JEEP order #6 — Ireland, 13 days, no drama, receipts inside in c/coldchain · 1 points · 2 years ago

Kept a vial at room temperature for eleven days by accident. Tested it out of guilt. It was fine.

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comment on [Discussion] mg/mL is doing more work than we give it credit for in c/reconstitution · 171 points · 2 years ago

Agreed on the swirl. There is no reason to shake it and a good reason not to.

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comment on [Discussion] mg/mL is doing more work than we give it credit for in c/reconstitution · 67 points · 2 years ago

Not quite. Bacteriostatic and sterile water are not interchangeable for a multi-draw vial, and the difference is the preservative.

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comment on chargeback — 8 things I got wrong before I got it right in c/cryptopay · 31 points · 2 years ago

the memo field matters on the chains that use one

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comment on BPC-157 — 8 things I got wrong before I got it right in c/bpc157 · 133 points · 2 years ago

Purity by area percent tells you the sample is homogeneous. Mass spectrometry tells you what the homogeneous thing is. For a short peptide, the second question is the one worth paying for.

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comment on [Lab] 6th independent test on SWB — 99.1% on a claimed 99.0%, and the trend is the interesting part in c/orforglipron · 8 points · 2 years ago

Small fix — the two programme names got swapped upthread and it changes which population the figure came from.

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comment on the Apotheke thing finally clicked for me and I want to write it down in c/glp1eu · 95 points · 2 years ago

That is an authorisation question and you have answered a reimbursement one. They are decided by different bodies.

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comment on someone explain pentadecapeptide to me like I have not read a paper in years in c/bpc157 · 2 points · 2 years ago

short peptides are cheap, which cuts both ways

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comment on [Question] small molecule — what am I missing here in c/orforglipron · 15 points · 2 years ago

daily dosing, not weekly, so the exposure profile is different

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comment on [Question] small molecule — what am I missing here in c/orforglipron · 26 points · 2 years ago

Not convinced. Oral semaglutide is a peptide formulated with an absorption enhancer; the comparison you are making does not hold.

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comment on does lyophilised actually matter or is it forum lore at this point in c/coldchain · 114 points · 2 years ago

lyophilised powder is far more forgiving than the panic threads suggest

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comment on [Discussion] the mg/mL advice in here is 3 years out of date in c/reconstitution · 4 points · 2 years ago

Cosigning the round-number approach. Reconstituting to something awkward is how you end up drawing 27.5 units at six in the morning.

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comment on unpopular opinion: most of what gets said here about reconstitution is guesswork in c/reconstitution · 66 points · 2 years ago

The dead space question sent me down a rabbit hole for a week. It is a fraction of a unit and it is the same every draw.

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comment on three years of packaging threads, summarised so you do not have to read them in c/coldchain · -24 points · 2 years ago

transit temperature is a distribution, not a number

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comment on [Discussion] data logger is doing more work than we give it credit for in c/coldchain · 294 points · 2 years ago

A transit temperature logger records a distribution, and time above a threshold matters as much as peak temperature. That is the argument for logging rather than guessing.

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comment on reading concentration threads from 2024 and half of it aged badly in c/reconstitution · 111 points · 2 years ago

bacteriostatic water has the preservative, sterile water does not

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