help me understand SURMOUNT, I have read the wiki twice
The title is the whole question — help me understand SURMOUNT, I have read the wiki twice — but here is why I am asking. Discontinuation rates are a tolerability result. A trial with a strong efficacy number and heavy discontinuation is telling you two things and people only quote one. The registered protocol is…
check who the comparator was before you compare anything
Correction: SURMOUNT is the obesity programme and SURPASS is the diabetes one. The figure you quoted belongs to the other one.
a mean is not a promise
Read a press release and the publication three months apart. The hedging in the second one was substantial.
a mean is not a promise
Agreed. And the interval, not the point estimate, is what the trial actually established.
STEP is semaglutide obesity, SURMOUNT is tirzepatide obesity, they are not interchangeable
This. Intention-to-treat versus completer analysis routinely moves the headline by several points.
This.
This is the distinction that would end about half the arguments on this board.
What did the confidence interval look like?
registry entry, protocol, publication — three different documents
That is the 68-week readout, not the 72-week one. Different trial, different duration.