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c/trialwatch·submitted 1 year ago by u/rulebook_rachael

SURPASS — 17 things I got wrong before I got it right

Paperbranch of 9 comments

SURPASS — 17 things I got wrong before I got it right, which sounds obvious until you try to state the evidence for it. Discontinuation rates are a tolerability result. A trial with a strong efficacy number and heavy discontinuation is telling you two things and people only quote one. Read a press release and the…

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9 comments, started 1 year ago
u/renal_outcomes_rMOD16 points·1 year ago

Added the trial identifier to the title so this thread is findable in two years.

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u/nhs_waitlist_nUK4 points·1 year ago

Careful with that mean. The distribution around it was wide enough that it describes very few individual participants.

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u/tb500_tangent4 points·1 year ago

Careful with that mean.

nhs_waitlist_n is right about the programme names. They are different populations with different endpoints.

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[deleted]3 points·1 year ago

[deleted]

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u/rulebook_rachaelOPmod · c/meta2 points·1 year ago

How long was the randomised phase before any extension?

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u/sofia_wikstrom1 point·1 year ago

That is a relative risk reduction. Quoting it without the absolute numbers overstates the case considerably.

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u/week_four_wall1 point·1 year ago

Agreed on comparators. "Superior" means nothing until you know superior to what and at what dose.

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u/trialwatch_theotrial nerd9 points·1 year ago

The press release said that; the publication says something more hedged. Worth reading both.

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u/hazard_ratio_halstats0 points·1 year ago

The press release said that; the publication says something more hedged.

Agreed. And the interval, not the point estimate, is what the trial actually established.

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