GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of how much of what we believe about endpoint actually comes from FLOW threads — 31 comments in the full submission. View in context.
479
c/trialwatch·submitted 2 months ago by u/nhs_waitlist_n

how much of what we believe about endpoint actually comes from FLOW threads

Statsbranch of 7 comments

Question in the title, detail here: how much of what we believe about endpoint actually comes from FLOW threads. Went looking for the registered protocol to see whether the endpoint had changed. It had not, which was reassuring and worth checking. How to read one of these papers in fifteen minutes, in the order that…

Read the full submission and all 31 comments →

This branch

7 comments, started 2 months ago
u/milos_trevino54 points·2 months ago

Absolute or relative risk reduction?

replysharereportpermalink
u/whois_wanda27 points·2 months ago·edited

Do you have the publication or the press release?

replysharereportpermalink
u/nhs_waitlist_nOPUK16 points·2 months ago

Do you have the publication or the press release?

Agreed. And the interval, not the point estimate, is what the trial actually established.

replysharereportpermalink
u/nils_tulloch10 points·2 months ago

Is that intention-to-treat or completers?

replysharereportpermalink
u/yusuf_ramos12 points·2 months ago

Agreed.

Disagreeing with this line: that is a relative reduction and the absolute numbers are considerably less dramatic.

replysharereportpermalink
[deleted]35 points·2 months ago

[deleted]

replysharereportpermalink
u/hamza_weiss51 points·2 months ago

What did the confidence interval look like?

replysharereportpermalink

← back to the whole thread

About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
More in c/trialwatch
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/trialwatch_theou/forest_plot_fionau/hazard_ratio_halu/renal_outcomes_r
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →