does SELECT actually matter or is it forum lore at this point
The title is the whole question — does SELECT actually matter or is it forum lore at this point — but here is why I am asking. Went looking for the registered protocol to see whether the endpoint had changed. It had not, which was reassuring and worth checking. Started keeping the trial identifiers straight in a note…
The press release said that; the publication says something more hedged. Worth reading both.
Correcting myself upthread: I gave the completer figure and labelled it intention-to-treat.
Disagree — that figure is from the diabetes programme and you are quoting it as an obesity endpoint.
Quoted a figure here confidently, got asked whether it was ITT, went and checked, and it was not. Learned something.
SELECT was cardiovascular outcomes, not weight
the appendix is where the interesting tables live
The discontinuation numbers were the most useful thing in the paper for me and they were in a supplementary table.
Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.
Cardiovascular outcome trials are powered for events, not for weight, and are typically run in a different population with different inclusion criteria. Reading a weight number out of one is reading a secondary endpoint.