[Question] endpoint — what am I missing here
endpoint — what am I missing here. I would rather ask a basic question now than get this wrong quietly for two months. Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about. Quoted a figure here confidently, got asked whether it was ITT, went and…
Careful with that mean. The distribution around it was wide enough that it describes very few individual participants.
Yes. The appendix tables are where the subgroup and the adverse event detail actually live.
Intention-to-treat analyses everybody randomised regardless of what they did afterwards. Completer analyses only those who finished. The second is systematically more flattering and both are legitimate if labelled.
Intention-to-treat analyses everybody randomised regardless of what they did afterwards.
Agreed. And the interval, not the point estimate, is what the trial actually established.
the confidence interval is the finding, the point estimate is the headline
a press release is not a publication
Open-label extensions lose their randomisation. Anybody still enrolled at week 104 is a selected group and the numbers describe that group.
phase 2 finds a dose, phase 3 measures the effect