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c/trialwatch·submitted 1 months ago by u/yusuf_ramos

[PSA] STEP is not what most of this community thinks it is

Discussionbranch of 8 comments

STEP is not what most of this community thinks it is — with the reasoning, because a rule without a reason gets ignored. On means, which this board treats as targets and which are nothing of the sort. A reported mean body weight change is the centre of a distribution that in these trials is very wide. Substantial…

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8 comments, started 1 months ago
u/foam_head_fred5 points·1 months ago

The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.

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u/niels_norgaard4 points·1 months ago

Yes — the interval is the finding. A point estimate with a wide interval is a hypothesis in a nice font.

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u/nora_oyelaran3 points·1 months ago

Careful with that mean. The distribution around it was wide enough that it describes very few individual participants.

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u/blunt_coldbox_notes1 point·1 months ago

read the endpoint before you read the headline

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u/hedda_adeyemi1 point·1 months ago

trial populations get support that nobody on this board gets

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u/nora_oyelaran1 point·1 months ago

read the endpoint before you read the headline

Adding the check nobody runs — the registered protocol is public and takes two minutes to compare.

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u/britta_boateng1 point·1 months ago

Adding the check nobody runs — the registered protocol is public and takes two minutes to compare.

nora_oyelaran is right about the programme names. They are different populations with different endpoints.

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u/yusuf_ramosOP1 point·1 months ago

Went looking for the registered protocol to see whether the endpoint had changed. It had not, which was reassuring and worth checking.

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