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c/tirzepatide·submitted 1 year ago by u/teodor_szabo

[Question] is 93.7% actually fine or am I being sold a rounding error

Questionbranch of 11 comments

Right: is 93.7% actually fine or am I being sold a rounding error. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. The numbers the title promised, since a headline without them is worthless: 93.7%. Everything below is context for those. Vials and pens carry the same…

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11 comments, started 1 year ago
u/aurel_lindqvist-16 points·1 year ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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u/sanne_novak1 point·1 year ago

pens and vials are the same molecule, the price is the difference

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u/gentle_correctionnice about it1 point·1 year ago

hold the dose that works, the ladder is not a leaderboard

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u/sofia_nascimento1 point·1 year ago

Are you comparing yourself with the trial mean or with the people who post the most?

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u/teodor_szaboOP1 point·1 year ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/hassan_nilsen1 point·1 year ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/bastian_eriksen1 point·1 year ago

I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your fatigue pattern is a guess.

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[removed]1 point·1 year ago

[removed by moderator]

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u/amara_halonen1 point·1 year ago·edited

2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.

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u/swirl_dont_shakereconstitution1 point·1 year ago

the trials titrated on a calendar, real people titrate on symptoms

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u/coring_the_stopper1 point·1 year ago·edited

Pen or vial? The step sizes available differ and it changes this answer.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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