[Meta] the GIP rule is doing its job and people should stop complaining
Putting this to the board: the GIP rule is doing its job and people should stop complaining. On comparing yourself with the trial number. SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the…
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
the four-week step schedule is the label, not folklore
pens and vials are the same molecule, the price is the difference
This matches mine. Milder injection-site soreness than I expected, and what there was settled inside a fortnight of each step.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.