how much of what we believe about GIP actually comes from SURMOUNT threads
Trying to get a straight answer on this: how much of what we believe about GIP actually comes from SURMOUNT threads.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
The step schedule question, answered properly, because it comes up weekly.
The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.
What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.
Week 10 was the first time the scale moved after a five-week stall. I changed nothing in that window.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Correction to my own post above — I said 2.5mg and I have been on 15mg since the spring. Same argument, wrong number.
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What step are you on and how long have you been there?
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
What is the waist doing? That is usually the number still moving during a scale stall.
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
Agree.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your injection-site soreness pattern is a guess.
I would separate the two claims.
Saving this one. It is the clearest statement of the stall problem I have read here.
a lot of people plateau nicely at 10mg and never need 15
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
the four-week step schedule is the label, not folklore
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Does food noise follow the day after the shot, or is it spread across the week?
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Same experience with the appetite effect being flatter across the week rather than front-loaded.
sulphur burps are the signature complaint and they are not dangerous
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
- 1What is the waist doing? That is usually the number still moving during a…11 comments in this branch · started by u/elin_varga
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