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c/tirzepatide·submitted 6 months ago by u/piotr_nascimento

how much of what we believe about GIP actually comes from SURMOUNT threads

Labbranch of 8 comments

Trying to get a straight answer on this: how much of what we believe about GIP actually comes from SURMOUNT threads. On comparing yourself with the trial number. SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It…

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8 comments, started 6 months ago
u/emil_okwuosa246 points·6 months ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

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u/cormac_pereira128 points·6 months ago

Does food noise follow the day after the shot, or is it spread across the week?

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u/piotr_nascimentoOP58 points·6 months ago

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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u/zeynep_zielinski41 points·6 months ago

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

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u/aurel_lindqvist203 points·6 months ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/dario_vermeulen83 points·6 months ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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u/incretin_ivypharmacology63 points·6 months ago

sulphur burps are the signature complaint and they are not dangerous

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u/tove_vasquez141 points·6 months ago

2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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