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c/tirzepatide·submitted 6 months ago by u/piotr_nascimento

how much of what we believe about GIP actually comes from SURMOUNT threads

Labbranch of 11 comments

Trying to get a straight answer on this: how much of what we believe about GIP actually comes from SURMOUNT threads. On comparing yourself with the trial number. SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It…

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11 comments, started 6 months ago
u/elin_varga-34 points·6 months ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/tove_vasquez1 point·6 months ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/tidy_vialdrawer_pls1 point·6 months ago

Agree.

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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u/forest_plot_fionastats1 point·6 months ago

Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.

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u/titration_marshalmod · c/semaglutide1 point·6 months ago

Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.

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u/rania_diallo1 point·6 months ago

I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your injection-site soreness pattern is a guess.

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u/nabila_ogunleye1 point·6 months ago

I would separate the two claims.

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/throwaway_wl20261 point·6 months ago

a lot of people plateau nicely at 10mg and never need 15

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u/nordic_pricing1 point·6 months ago

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

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u/copay_card_cc1 point·6 months ago

the four-week step schedule is the label, not folklore

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u/piotr_nascimentoOP1 point·6 months ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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