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c/tirzepatide·submitted 8 months ago by u/ferritin_low

switched from 5mg to 15mg and constipation got better, not worse

Labbranch of 18 comments

Thinking out loud about this: switched from 5mg to 15mg and constipation got better, not worse. Hard numbers: 5mg and 15mg. Anything softer than that is flagged as an impression. The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week. Appetite effect…

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This branch

18 comments, started 8 months ago
u/quiet_moderatorMOD143 points·8 months ago

Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.

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u/hugo_bergstrom70 points·8 months ago

Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.

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u/nordic_pricing58 points·8 months ago

12kg over 46 weeks, never went past 10mg, and reflux stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/ingrid_correia0 points·8 months ago

12kg over 46 weeks, never went past 10mg, and reflux stayed mild the whole way.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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u/ferritin_lowOP27 points·8 months ago

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

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u/dario_vermeulen19 points·8 months ago

pens and vials are the same molecule, the price is the difference

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u/neha_falk76 points·8 months ago

Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.

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u/cormac_pereira61 points·8 months ago

2.5 is the starter dose and it is not meant to be the dose that works

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u/aurel_lindqvist111 points·8 months ago

if 7.5 is working, 10 is not automatically better

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u/bastian_ekstrom32 points·8 months ago

the nausea profile is genuinely gentler than people expect coming from sema

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u/throwaway_titration21 points·8 months ago·edited

Week 31 was the first time the scale moved after a five-week stall. I changed nothing in that window.

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u/curious_panel_only13 points·8 months ago

Have you held a step for longer than the four-week minimum at any point?

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u/cato_girard9 points·8 months ago·edited

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/yusuf_ramos96 points·8 months ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/alcohol_aversion39 points·8 months ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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