[Vendor] QST vs WWB on the same compound, same month — both cleared 99.0%
Filing this under things worth writing down: QST vs WWB on the same compound, same month — both cleared 99.0%. Figures up front so nobody has to dig: 99.0%. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled. 41kg over 86 weeks, never went past…
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
The step schedule question, answered properly, because it comes up weekly.
The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.
What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Does injection-site soreness follow the day after the shot, or is it spread across the week?
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your reflux pattern is a guess.
What is the waist doing? That is usually the number still moving during a scale stall.
What is the waist doing?
Saving this one. It is the clearest statement of the stall problem I have read here.
the constipation profile is genuinely gentler than people expect coming from sema