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c/t2dglp1·submitted 1 year ago by u/not_my_main_nm

anyone else notice hypoglycaemia kicking in around week 8

Cautionbranch of 6 comments

Check-in as promised in the title: anyone else notice hypoglycaemia kicking in around week 8. On hypoglycaemia, because the risk gets attributed to the wrong thing constantly. Incretin-based agents stimulate insulin secretion in a glucose-dependent way: the effect scales with glycaemia rather than acting…

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6 comments, started 1 year ago
u/bianca_dziedzic29 points·1 year ago

Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low. Risk rises with agents that act independently of glycaemia.

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u/britt_abubakar7 points·1 year ago

A1c is a three-month average and it lags everything

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u/nadia_norgaard10 points·1 year ago

Brought the whole CGM export to my appointment rather than one number. Entirely different conversation.

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u/protein_first_pnutrition8 points·1 year ago

That A1c change is inside the assay’s variability and the interval you measured over is too short.

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u/hassan_ostergaard5 points·1 year ago

Small fix — insulin secretion in this class is glucose-dependent, which is precisely why the risk you describe comes from the other agent.

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[removed]11 points·1 year ago

[removed by moderator]

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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