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c/retatrutide·submitted 8 months ago by u/yannick_barros

reading retatrutide threads from 2024 and half of it aged badly

Cautionbranch of 9 comments

reading retatrutide threads from 2024 and half of it aged badly. Not a hot take, just something I have not seen said plainly here. The thing that surprised me was how much of the discussion here is inference rather than measurement. Watched heart rate on a wearable across twelve weeks because the threads said to. It…

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9 comments, started 8 months ago
u/cold_chromatogram_only219 points·8 months ago

Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.

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u/yannick_barrosOP157 points·8 months ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

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u/reflux_report89 points·8 months ago

Right, and it bears repeating that nothing here is approved anywhere and research material is not for human use.

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u/nausea_notesside effects44 points·8 months ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/marit_laurent12 points·8 months ago

Has anyone posted an independent test on this compound recently?

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u/marta_vanhecke23 points·8 months ago

the energy-expenditure story is mechanistically interesting and clinically unproven

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u/honest_syringe339 points·8 months ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/niels_lindqvist10 points·8 months ago

not approved anywhere, which is the single most important fact in this board

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u/employer_carveout4 points·8 months ago

the phase 2 numbers were striking and they were also 48 weeks in a small population

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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