[Results] 45 weeks on 0.25mg, full numbers, ask me anything boring
Check-in as promised in the title: 45 weeks on 0.25mg, full numbers, ask me anything boring. The numbers the title promised, since a headline without them is worthless: 45 weeks and 0.25mg. Everything below is context for those. Kept a log specifically because there is so little published. It is one person and it is…
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
a lot of the confident posting here is extrapolation
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
The muscle cramps profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
It is a triple agonist at the GLP-1, GIP and glucagon receptors.
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.