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c/retatrutide·submitted 1 year ago by u/yannick_barros

unpopular opinion: most of what gets said here about phase 2 is guesswork

Trial Databranch of 7 comments

unpopular opinion: most of what gets said here about phase 2 is guesswork. Change my mind, genuinely — I have no stake in being right about this. The standing caveat, written out properly because it keeps getting compressed into a footnote. Nothing containing this compound is approved by any regulator.…

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This branch

7 comments, started 1 year ago
u/aa_analysis_andy184 points·1 year ago

The thing that surprised me was how much of the discussion here is inference rather than measurement.

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u/yannick_salinas150 points·1 year ago

heart rate is the thing people report watching

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u/yannick_barrosOP112 points·1 year ago

heart rate is the thing people report watching

Agreed, and the glucagon arm is exactly why the comparison threads do not work.

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u/yusuf_ramos91 points·1 year ago

the escalation is where most of the reported trouble sits

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u/iman_castellanos34 points·1 year ago

phase 2 data only, and people quote it like it is a label

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u/yannick_barrosOP0 points·1 year ago

Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.

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u/cold_chromatogram_only1 point·1 year ago

Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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