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c/glp1science·submitted 9 months ago by u/yannick_barros

[PSA] gastric emptying is not what most of this community thinks it is

Needs Sourcebranch of 6 comments

Short public-service post: gastric emptying is not what most of this community thinks it is. GLP-1 receptor agonism acts both peripherally — insulin secretion in a glucose-dependent way, slowed gastric emptying — and centrally, on appetite regulation. The central component is the better explanation for sustained…

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6 comments, started 9 months ago
u/slow_logbook23 points·9 months ago

Started reading limitations sections first. It has changed how much weight I give to almost everything posted here.

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u/laila_almeida6 points·9 months ago

Yes. The discussion section is where the authors say what they actually think, and almost nobody here reads it.

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u/lina_ndiaye3 points·9 months ago

receptor agonism is not the same as receptor activation in every tissue

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u/kavya_kravchenko1 point·9 months ago

receptor agonism is not the same as receptor activation in every tissue

lina_ndiaye is right that mechanism gives direction and not magnitude. Worth pinning.

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u/marisol_kravchenko0 points·9 months ago

Same view. Tolerance developing to the gastric effect while the appetite effect persists explains most of what the side-effect board reports.

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u/nurse_ish_20251 point·9 months ago

receptor distribution is why the side effects are where they are

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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