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c/glp1science·submitted 11 months ago by u/yannick_barros

appetite is the most under-discussed thing on this board

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appetite is the most under-discussed thing on this board. Change my mind, genuinely — I have no stake in being right about this. GIP receptor biology is genuinely unsettled — there is a live argument about agonism versus antagonism at the receptor — and the clinical results are robust regardless, which is an…

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7 comments, started 11 months ago
u/devils_advocate_d63 points·11 months ago

What was the exposure in that experiment relative to therapeutic?

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u/gastric_emptying_gMOD46 points·11 months ago

Retitled to distinguish preclinical from clinical, which the original ran together.

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u/ingrid_correia66 points·11 months ago

Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.

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u/priya_guerrero38 points·11 months ago·edited

What was the exposure in that experiment relative to therapeutic?

Agreed — and it is why the central and peripheral stories are complementary rather than rival.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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