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c/glp1science·submitted 9 months ago by u/sanne_delgado

[Question] mechanism — what am I missing here

Questionbranch of 7 comments

mechanism — what am I missing here. I am not trying to be the "source?" guy. I would just like a source. Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally. Tolerance to the gastric effect develops with continued…

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7 comments, started 9 months ago
u/neha_krastev55 points·9 months ago

preclinical is not clinical and rodents are not small people

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u/viktor_girard43 points·9 months ago

tolerance to the gastric effect develops, appetite effect largely persists

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u/bastian_ekstrom23 points·9 months ago

the central appetite effect is doing more work than the gut effect

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u/aksel_palacios15 points·9 months ago

mechanism explains a direction, not a magnitude

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u/sanne_delgadoOP5 points·9 months ago

Asked a question here that I thought was stupid and got three papers back. Best thread I have been in on this site.

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u/neha_krastev9 points·9 months ago·edited

mechanism explains a direction, not a magnitude

Agreed — and it is why the central and peripheral stories are complementary rather than rival.

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u/sanne_delgadoOP7 points·9 months ago

What does the discussion section say about the limitation you are glossing?

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