[Question] how do you actually verify half-life
how do you actually verify half-life. I am not trying to be the "source?" guy. I would just like a source. Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally. Tolerance to the gastric effect develops with continued…
Long half-life in this class comes from structural modification that promotes albumin binding and resists enzymatic degradation. Weekly dosing is a consequence of the molecule, not a convenience decision.
a mechanism you can state is not a mechanism you have demonstrated
albumin binding is most of the half-life story
the peripheral and central stories are not in competition
the peripheral and central stories are not in competition
Disagreeing with this specific inference — that is a preclinical result being read as human pharmacology.
glucagon agonism sounds paradoxical until you read the energy expenditure work