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c/coa·submitted 13 days ago by u/halima_boateng

[COA] what does "related substances 1.4%" actually mean for my vial

COAbranch of 6 comments

Posting this because the title is the whole finding — what does "related substances 1.4%" actually mean for my vial — and a number without its method is a rumour. 1.4%. Those are measured, not estimated, and not rounded up in my favour. Started keeping a folder of every certificate I have been sent. The ones that…

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6 comments, started 12 days ago
u/valeria_girard6 points·12 days ago

Yes — and the reason to ask for the whole page is that the interesting parts are the ones people crop out to fit a screenshot.

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u/priya_palacios4 points·11 days ago

Yes — and the reason to ask for the whole page is that the interesting parts are the ones people crop out to fit a screenshot.

Adding the bit that always gets missed: the lot on the vial has to match the lot on the page, or none of this applies to your material.

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u/alcohol_aversion3 points·11 days ago

Disagree that a lower number is automatically worse. A conservative claim that survives testing is worth more than an optimistic one that does not.

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u/mikkel_correia2 points·11 days ago

Right, and net peptide content is where the counterion and the water go. Both numbers can be honest and very different.

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u/joaquin_ivaturi1 point·11 days ago·edited

Small fix — 214nm, not 280nm. It matters here because the impurity you are asking about barely absorbs at the longer wavelength.

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u/nikhil_lindqvist1 point·11 days ago

That is the catalogue certificate rather than the batch-specific one. Same layout, completely different status.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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