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c/cagrilintide·posted 2 years ago by u/yannick_petrov

small win: cagrilintide stopped being a problem at week 75

Lab Long Haul ×9 Slow Clap ×1

small win: cagrilintide stopped being a problem at week 75. Numbers below. Ask me the boring questions, they are the useful ones.

Dosing intuitions from the GLP-1 boards do not transfer. Different receptor family, different exposure-response, and no published schedule for members to reason from.

Carried an assumption over from the tirzepatide board and was corrected within an hour. Deserved.

That is everything I have. The rest is opinion and I have tried to keep it out.

1,811 up / 371 down83% upvoted47 commentsid 1cybse25 Apr 2024

47 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/noor_hovland145 points·2 years ago

Independent purity data on this compound is sparse compared with the older molecules, simply because far fewer members have paid for testing. Sparse data means wide uncertainty, not a verdict.

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u/amara_halonen-34 points·2 years ago

Asked a question here that turned out to be based on a mechanism confusion. Three people untangled it patiently.

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u/yannick_petrovOP1 point·2 years ago

Which receptor family are you attributing that effect to?

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u/georgi_chowdhury1 point·2 years ago

Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories.

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u/liv_kuipers1 point·2 years ago

satiety signalling rather than incretin signalling

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u/rania_salinas126 points·2 years ago

Careful — that is a dosing intuition carried over from another board and there is no basis for it here.

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u/zeynep_zielinski71 points·2 years ago

I would not extrapolate the tolerability profile from the monotherapy arm to the combination. The trials report them separately for a reason.

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[removed]51 points·2 years ago

[removed by moderator]

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u/yannick_petrovOP32 points·2 years ago

The tolerability tables were more informative than the headline numbers, which is usually the case and never how it gets summarised.

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u/marta_ilunga8 points·2 years ago

read the combination arms separately from the monotherapy arms

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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