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c/cagrilintide·submitted 2 years ago by u/yannick_petrov

small win: cagrilintide stopped being a problem at week 75

Labbranch of 6 comments

small win: cagrilintide stopped being a problem at week 75. Numbers below. Ask me the boring questions, they are the useful ones. Dosing intuitions from the GLP-1 boards do not transfer. Different receptor family, different exposure-response, and no published schedule for members to reason from. Carried an assumption…

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6 comments, started 2 years ago
u/noor_hovland145 points·2 years ago

Independent purity data on this compound is sparse compared with the older molecules, simply because far fewer members have paid for testing. Sparse data means wide uncertainty, not a verdict.

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u/amara_halonen-34 points·2 years ago

Asked a question here that turned out to be based on a mechanism confusion. Three people untangled it patiently.

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u/yannick_petrovOP1 point·2 years ago

Which receptor family are you attributing that effect to?

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u/georgi_chowdhury1 point·2 years ago

Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories.

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u/liv_kuipers1 point·2 years ago

satiety signalling rather than incretin signalling

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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