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u/tomas_kimani

Contributes reviews on supplier material. Based in Basel.

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Comments — page 2 of 3

comment on why does nobody talk about SELECT in c/trialwatch · 34 points · 5 months ago

Cosigning on discontinuation. It is a result about tolerability and it gets buried every time.

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comment on [Question] how do you actually verify glycaemic control in c/t2dglp1 · 17 points · 5 months ago

Yes — time in range tells you about variability, which the average deliberately hides.

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comment on the regulatory thing finally clicked for me and I want to write it down in c/bpc157 · -35 points · 5 months ago

Purity by area percent tells you the sample is homogeneous. Mass spectrometry tells you what the homogeneous thing is. For a short peptide, the second question is the one worth paying for.

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comment on Poland: shortage, and what it actually costs here in c/glp1aus · 1 points · 5 months ago

Personal importation provisions exist, are narrow, and carry conditions.

This is the distinction that makes the rest of the board legible.

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comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 0 points · 5 months ago

The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.

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comment on [Lab] 12th independent test on SGN — 98.1% on a claimed 98.0%, and the trend is the interesting part in c/bpc157 · 1 points · 5 months ago

Was there identity confirmation, or only a purity figure?

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comment on why does nobody talk about dead space in c/reconstitution · 35 points · 5 months ago

Careful — that arithmetic is wrong. 15mg in 2mL is 7.5mg/mL, so 0.75mg draws to 10 units, not what you wrote.

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comment on why does nobody talk about baseline labs in c/bloodwork · 2 points · 5 months ago

What did the repeat show?

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comment on help me understand lean mass, I have read the wiki twice in c/glp1muscle · 14 points · 6 months ago

Lost slower for six months deliberately and my composition change was not obviously different. Training was what mattered.

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comment on [Results] 17 weeks, 6kg, and cagrilintide was the hard part in c/cagrilintide · 35 points · 6 months ago

Same view — long-acting is the engineering achievement here, and it is why the molecule exists at all.

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comment on titration is the most under-discussed thing on this board in c/semaglutide · 1 points · 6 months ago

the ladder exists because the gut needs the time, not because the pharmacy likes paperwork

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comment on is it normal to get food noise at week 20 in c/glp1muscle · 1 points · 6 months ago

That protein figure is grams per day, not grams per kilogram. Different claim entirely.

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comment on the units thing finally clicked for me and I want to write it down in c/reconstitution · 131 points · 6 months ago

Adding more water does not change how much peptide is in the vial. It changes the concentration, which changes the volume you draw for the same amount. That is the entire relationship.

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comment on [Results] 89 weeks on 1.7mg, full numbers, ask me anything boring in c/semaglutide · 145 points · 6 months ago

Are you measuring anything other than weight? Waist is usually the one that keeps moving.

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comment on three years of sequence threads, summarised so you do not have to read them in c/bpc157 · 3 points · 7 months ago

Agreed — cheap to make is a double-edged fact and it explains a lot about this corner of the market.

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comment on small win: A1c stopped being a problem at week 48 in c/bloodwork · 52 points · 7 months ago

Reference intervals are typically the central 95% of a reference population. By construction one person in twenty falls outside one on any given test without anything being wrong.

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comment on how much of what we believe about endpoint actually comes from SELECT threads in c/trialwatch · 211 points · 7 months ago

Careful with that mean. The distribution around it was wide enough that it describes very few individual participants.

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comment on [Question] co-agonism — what am I missing here in c/cagrilintide · 50 points · 7 months ago

long-acting amylin is the whole point of the molecule

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comment on the Australia thing finally clicked for me and I want to write it down in c/glp1aus · 4 points · 7 months ago

Subsidy criteria and authority requirements are published. For eligibility questions those documents are authoritative and this board is not.

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comment on the Australia thing finally clicked for me and I want to write it down in c/glp1aus · 53 points · 7 months ago

Australia and New Zealand have different regulators, different funding bodies and different arrangements. An answer for one is not evidence about the other.

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comment on the STEP question that gets asked weekly, answered properly in c/trialwatch · 12 points · 7 months ago

Right — trial participants get structured support. Comparing yourself to a trial mean is comparing across two different interventions.

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comment on week 39 check-in — 12kg down, injection-site soreness manageable, one thing confusing me in c/bpc157 · 97 points · 8 months ago

What jurisdiction are you asking about? The answer has changed in several.

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comment on SURPASS — 6 things I got wrong before I got it right in c/trialwatch · 24 points · 8 months ago

Yes. The appendix tables are where the subgroup and the adverse event detail actually live.

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comment on [Question] how do you actually verify reconstitution in c/reconstitution · 95 points · 8 months ago

Adding more water does not change how much peptide is in the vial. It changes the concentration, which changes the volume you draw for the same amount. That is the entire relationship.

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comment on titration: what the trials say vs what this community says in c/semaglutide · 190 points · 9 months ago

How long was the stall before you decided it was a stall?

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comment on [PSA] pentadecapeptide is not what most of this community thinks it is in c/bpc157 · 13 points · 9 months ago

sequence confirmation is the test worth paying for

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comment on [Lab] 20th independent test on FGP — 98.6% on a claimed 98.0%, and the trend is the interesting part in c/cagrilintide · 5 points · 9 months ago

I would not extrapolate the tolerability profile from the monotherapy arm to the combination. The trials report them separately for a reason.

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comment on [Lab] 8th independent test on MKM — 97.9% on a claimed 97.5%, and the trend is the interesting part in c/semaglutide · 47 points · 9 months ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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comment on help me understand rodent data, I have read the wiki twice in c/bpc157 · -34 points · 9 months ago

It is a fifteen-residue peptide with a published sequence, which makes synthesis straightforward and makes identity verification the meaningful test rather than an optional extra.

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comment on [Discussion] concentration is doing more work than we give it credit for in c/reconstitution · 1 points · 10 months ago

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

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comment on mg/mL is the most under-discussed thing on this board in c/reconstitution · 80 points · 10 months ago

Wrote the date on the vial as well as the concentration after losing track of which one was opened first.

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comment on anyone else notice pentadecapeptide kicking in around week 54 in c/bpc157 · 46 points · 10 months ago

Push back: "no reported harms" in a literature with almost no human trials is not a safety finding.

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comment on three years of CagriSema threads, summarised so you do not have to read them in c/cagrilintide · 1 points · 1 year ago

Do you have the publication or a summary of it?

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comment on [Discussion] amylin is doing more work than we give it credit for in c/cagrilintide · 18 points · 1 year ago

Cosigning on the thin independent data. Fewer members test this, so the bands are wider and should be treated that way.

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comment on ferritin — my 22-week log, condensed into one table in c/bloodwork · 1 points · 1 year ago

Same lab as the previous draw?

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comment on anyone else notice lipids kicking in around week 9 in c/bloodwork · 65 points · 1 year ago

Have you taken this to whoever ordered it?

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comment on [Results] 37 weeks, 6kg, and weekly dosing was the hard part in c/semaglutide · 14 points · 1 year ago

the first four weeks are a tolerance check, not a weight-loss phase

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comment on [Question] DEXA — what am I missing here in c/glp1muscle · 100 points · 1 year ago

Nothing here is a training or nutrition prescription. Targets and programmes are matters for somebody who knows your history and your training background.

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comment on stalled for 6 weeks at 1.7mg and I refuse to panic this time in c/bloodwork · 18 points · 1 year ago

Small fix — a reference interval is not a treatment target, and the post above uses them interchangeably.

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comment on units — 21 things I got wrong before I got it right in c/reconstitution · 16 points · 1 year ago

if the maths gives you a fraction of a unit, change the concentration

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