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u/placebo_arm_pam

The placebo arm lost weight too. Always ask by how much.

member · joined 30 Mar 2024

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Overview — page 2 of 2

comment on help me understand gallbladder, I have read the wiki twice in c/sideeffects · 400 points · 11 months ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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comment on [Question] how do you actually verify rules in c/meta · 1 points · 12 months ago

Right, and the storefront links on source pages are marked and disclosed, which is the honest way to do it.

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comment on [Results] 39 weeks, 17kg, and progress was the hard part in c/progresspics · 30 points · 1 year ago

Gently disagree with the framing — that is not a plateau, that is a month. They are different things.

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comment on what would you tell week-1 you about glucagon in c/retatrutide · -38 points · 1 year ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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comment on help me understand nausea, I have read the wiki twice in c/sideeffects · 1 points · 1 year ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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comment on three years of reflux threads, summarised so you do not have to read them in c/sideeffects · 430 points · 1 year ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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comment on [Lab] split one vial across VendorInvestigate and PeptideMeter — 98.6% and 93.7% in c/retatrutide · 22 points · 1 year ago

Kept a log specifically because there is so little published. It is one person and it is not data.

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comment on dose escalation — my 16-week log, condensed into one table in c/retatrutide · 110 points · 1 year ago

Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.

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comment on stalled for 12 weeks at 10mg and I refuse to panic this time in c/retatrutide · 36 points · 1 year ago

the phase 2 numbers were striking and they were also 48 weeks in a small population

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comment on [Discussion] can we stop arguing about ranking until somebody posts a number in c/meta · 3 points · 1 year ago

This. Modmail first is not bureaucracy; it stops individual cases turning into a public pile-on.

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comment on 15 months in and struggle is still the thing I get wrong in c/progresspics · 6 points · 1 year ago

comparison is the thief of everything on a board like this

kian_ferreira is right that the clothes tell you before the scale does.

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comment on three years of wiki threads, summarised so you do not have to read them in c/meta · 31 points · 1 year ago

A rule-change proposal needs replacement wording because that is what can be evaluated. Without it there is nothing to compare against the current text.

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comment on am I the only one who found triple agonist harder than the injections in c/retatrutide · 15 points · 1 year ago

small trial, big effect, wide error bars

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comment on gallbladder — 15 things I got wrong before I got it right in c/sideeffects · 41 points · 1 year ago

reflux at night, try not eating in the three hours before bed

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comment on 3 months in and triple agonist is still the thing I get wrong in c/retatrutide · 64 points · 1 year ago

phase 2 data only, and people quote it like it is a label

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comment on help me understand progress, I have read the wiki twice in c/progresspics · 9 points · 1 year ago

Wrote down one non-scale thing every week. Reading a year of those back was more affecting than any number.

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comment on the disclosure question that gets asked weekly, answered properly in c/meta · 21 points · 1 year ago

Read the ranking formula out of scepticism and reproduced the ordering in a spreadsheet. It does what it says.

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comment on the disclosure question that gets asked weekly, answered properly in c/meta · 2 points · 1 year ago

What is the concrete wording you would replace it with?

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comment on the disclosure question that gets asked weekly, answered properly in c/meta · 6 points · 1 year ago

That is the controversial ordering, not the hot one. Different formula, different behaviour.

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comment on [Discussion] can we stop arguing about fatigue until somebody posts a number in c/sideeffects · 26 points · 2 years ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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comment on my TSH moved and I cannot work out whether sulphur burps are why in c/sideeffects · 192 points · 2 years ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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comment on [Question] heart rate — what am I missing here in c/sideeffects · 87 points · 2 years ago

fatigue plus low intake is usually just low intake

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comment on wiki — 21 things I got wrong before I got it right in c/meta · 44 points · 2 years ago

Edited a wiki page for the first time and nothing bad happened, which is apparently the point.

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comment on what changed for me between month 8 and month 12 in c/sideeffects · 197 points · 2 years ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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comment on genuine question about reflux that I am slightly embarrassed to ask in c/sideeffects · 127 points · 2 years ago

the food noise going quiet is the effect people came for, and reflux is the toll for the first fortnight

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comment on how much of what we believe about hair loss actually comes from gallbladder threads in c/sideeffects · 9 points · 2 years ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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comment on [Question] how do you actually verify hair loss in c/sideeffects · 562 points · 2 years ago

write down when it starts and stops, the pattern is the useful part

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comment on anyone else notice dose escalation kicking in around week 37 in c/retatrutide · 236 points · 2 years ago

comparing reta phase 2 to sema phase 3 is comparing different things

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