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u/incretin_ivy

GIP/GLP-1 co-agonism is genuinely interesting pharmacology, separate from the weight story.

long-standing contributor · pharmacology · joined 8 Jul 2024

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344comments

Overview — page 2 of 3

comment on [Failure] vendor vanished mid-order with 11 people waiting in c/darkspot · 30 points · 16 days ago

Gently disagree with the self-blame. What you describe is a procedural gap, and the procedure was not written down anywhere for you to follow.

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comment on reading non-peptide threads from 2024 and half of it aged badly in c/orforglipron · 5 points · 17 days ago

Corrected a cross-class dose comparison in the title. The body is untouched.

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comment on [Meta] proposal — a flair for dual agonist posts in c/survodutide · 23 points · 17 days ago

Independent result logged. There are almost none for this compound, so it is genuinely valuable.

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comment on anyone else find 15mg genuinely unpleasant with no extra loss in c/tirzepatide · 5 points · 17 days ago

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

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comment on the dose escalation question that gets asked weekly, answered properly in c/retatrutide · 80 points · 17 days ago

The standing caveat, written out properly because it keeps getting compressed into a footnote.

Nothing containing this compound is approved by any regulator. Research-use-only material is not approved for human use. That is not a legal formality on this board — it is why there is so little independent data, why the escalation schedules people post are invented, and why nobody here can answer a dosing question.

What this board can usefully do is read the published trials carefully, log independent purity results, and be honest about how thin the evidence base is. Everything else belongs somewhere with a clinician in it.

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comment on [Question] creatine while eating 1,400 calories — worth it in c/glp1muscle · 7 points · 18 days ago

Small fix — that is fat-free mass, not muscle mass. The scan cannot separate them the way the post assumes.

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comment on [Question] creatine while eating 1,400 calories — worth it in c/glp1muscle · 11 points · 19 days ago

Right — strength retention is a free proxy and it tracks better than most people expect.

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comment on why does nobody talk about ACHIEVE in c/orforglipron · 21 points · 20 days ago

daily dosing changes adherence in both directions

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comment on why does nobody talk about ACHIEVE in c/orforglipron · 26 points · 21 days ago

Left up. It is careful about what is peptide and what is not, which is more than most threads here manage.

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comment on [Discussion] the sarcopenia question nobody funded properly in c/glp1muscle · 14 points · 22 days ago

Correction: those scans are from different machines, and the difference you are describing is within the measurement error.

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comment on [Discussion] glucagon is doing more work than we give it credit for in c/retatrutide · 12 points · 24 days ago

Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.

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comment on [Discussion] the thymosin advice in here is 3 years out of date in c/researchpeptides · 40 points · 24 days ago

Correcting my own comment: the storage condition I quoted was for the lyophilised powder, not for solution.

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comment on [Discussion] glucagon is doing more work than we give it credit for in c/retatrutide · 66 points · 25 days ago

Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.

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comment on [Discussion] the thymosin advice in here is 3 years out of date in c/researchpeptides · 52 points · 25 days ago

Bought small on anything without a testing history here. That rule has never once cost me anything.

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comment on [Question] is 97.6% actually fine or am I being sold a rounding error in c/cagrilintide · 31 points · 26 days ago

Independent result added to the log. Thank you for paying for it — there are very few on this compound.

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comment on cagrilintide — 17 things I got wrong before I got it right in c/cagrilintide · 2 points · 1 months ago

Bought small deliberately because the evidence base is thin. That felt like the only defensible approach.

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comment on cagrilintide — 17 things I got wrong before I got it right in c/cagrilintide · 7 points · 1 months ago

That is preclinical work and the thread is treating it as a human finding.

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comment on cagrilintide — 17 things I got wrong before I got it right in c/cagrilintide · 1 points · 1 months ago

Standing reminder: nothing here is approved standalone, research material is not for human use, and no dosing schedules for other members.

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comment on cagrilintide — 17 things I got wrong before I got it right in c/cagrilintide · 1 points · 1 months ago

phase 3 data will change most of what gets said here

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comment on unpopular opinion: most of what gets said here about gastric emptying is guesswork in c/glp1science · 17 points · 1 months ago

Left up and flaired Explainer. This is the standard of post the board was created for.

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comment on [Results] 65 weeks on 15mg, full numbers, ask me anything boring in c/tirzepatide · 1 points · 1 months ago

if 7.5 is working, 10 is not automatically better

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comment on what changed for me between month 12 and month 18 in c/orforglipron · 3 points · 1 months ago

Standing reminder: unapproved compound, research material is not for human use, and no schedules for other members.

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comment on [Meta] proposal — a flair for glucagon posts in c/retatrutide · 1 points · 1 months ago

How fast was the escalation? That is usually the variable that explains the reports.

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comment on [Failure] two years in, stopped for financial reasons, regained most of it in c/darkspot · 10 points · 1 months ago

Hunan GoodPeptides Biotech shows up in these threads because nothing verifiable exists either way

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comment on [Discussion] we are measuring tirzepatide at the wrong time and calling it noise in c/tirzepatide · 11 points · 1 months ago

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

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comment on [Discussion] the telehealth advice in here is 3 years out of date in c/compounding · 8 points · 1 months ago

Correction: patient-specific refers to the prescription, not to a bespoke formulation. Common misreading and it changes the argument.

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comment on help me understand oral GLP-1, I have read the wiki twice in c/orforglipron · 8 points · 1 months ago

Retitled to name the programme. It is what makes these threads findable in a year.

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comment on [Discussion] the telehealth advice in here is 3 years out of date in c/compounding · 14 points · 1 months ago

Small fix — 503B facilities register with the regulator; 503A pharmacies are licensed by the state board. Different mechanisms.

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comment on [Discussion] the telehealth advice in here is 3 years out of date in c/compounding · 51 points · 1 months ago

Was there potency testing on the finished preparation, or only on the starting material?

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comment on [Lab] GGPeps survo — VendorInvestigate came back 97.9% against a claimed 97.0% in c/survodutide · 30 points · 1 months ago

Independent result logged. There are almost none for this compound, so it is genuinely valuable.

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comment on amylin — 23 things I got wrong before I got it right in c/cagrilintide · 145 points · 1 months ago

Is there any independent purity data on this compound that you have seen?

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comment on small win: dose escalation stopped being a problem at week 55 in c/retatrutide · 1 points · 1 months ago

Trial names corrected in the title. The phase 3 programme and the phase 2 readout are not the same thing.

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comment on small win: dose escalation stopped being a problem at week 55 in c/retatrutide · 11 points · 1 months ago

Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.

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comment on [Lab] split one vial across PeptideMeter and VendorInvestigate — 98.4% and 97.2% in c/tirzepatide · 90 points · 1 months ago

the trials titrated on a calendar, real people titrate on symptoms

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comment on anyone else notice oral GLP-1 kicking in around week 56 in c/orforglipron · 9 points · 1 months ago

Yes — nothing containing this is approved anywhere, and the threads keep forgetting it.

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comment on [Discussion] sarcopenia is doing more work than we give it credit for in c/glp1muscle · 7 points · 1 months ago

Agreed — protein and resistance training. Everything else in these threads is a rounding error on those two.

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comment on does incretin actually matter or is it forum lore at this point in c/glp1science · 1 points · 1 months ago

Yes. The central component is the one that explains the reports on this site better than gastric emptying does.

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comment on small win: glucagon stopped being a problem at week 32 in c/retatrutide · 0 points · 1 months ago

Not convinced. You are attributing a week of sulphur burps to the glucagon arm when the escalation rate alone would explain it.

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