small win: glucagon stopped being a problem at week 32
Six-word version is the title — small win: glucagon stopped being a problem at week 32 — and the rest is context.
Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.
The fatigue profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
I will update this if the picture changes rather than quietly leaving it up.
best — the order this archive was captured in
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
Stopped at a low step because there was no reason to go further and no data to tell me what further would do.
comparing reta phase 2 to sema phase 3 is comparing different things
Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.
a lot of the confident posting here is extrapolation
Push back: quoting the phase 2 headline as an expected outcome is not a fair reading of a small trial with wide intervals.
Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.
That reads as a titration plan for an unapproved compound. This board cannot host that and it should not want to.
a lot of the confident posting here is extrapolation
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
Not convinced. You are attributing a week of sulphur burps to the glucagon arm when the escalation rate alone would explain it.
Not convinced.
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.
- 1Disagree. "More receptors means more effect" is not how any of this works…6 comments in this branch · started by u/kavya_kravchenko