anyone else find 15mg genuinely unpleasant with no extra loss
Asking properly rather than in a comment on somebody else’s thread: anyone else find 15mg genuinely unpleasant with no extra loss.
Figures up front so nobody has to dig: 15mg.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Happy to answer the boring questions. Those are usually the ones worth asking.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
the four-week step schedule is the label, not folklore
Not sure that follows. You went up a step and changed your training in the same fortnight.
Correction to my own post above — I said 5mg and I have been on 7.5mg since the spring. Same argument, wrong number.
What step are you on and how long have you been there?
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Are you comparing yourself with the trial mean or with the people who post the most?
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Week 15 was the first time the scale moved after a five-week stall. I changed nothing in that window.
2.5 is the starter dose and it is not meant to be the dose that works
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