u/fasting_insulin_f
HOMA-IR is crude but free. Track it anyway.
member · joined 29 Feb 2024
comment on [PCOS] my androgens moved before my weight did and nobody had mentioned that was possible in c/glp1women · 118 points · 2 days ago
that is a big move on a small weight change and it is a much more interesting data point than the 9kg.
comment on [Caution] stacking with a sulfonylurea is a real hypo risk, not a theoretical one in c/t2dglp1 · 35 points · 2 days ago
Retitled — the original quoted an obesity endpoint as a glycaemic one.
comment on [Caution] stacking with a sulfonylurea is a real hypo risk, not a theoretical one in c/t2dglp1 · 2 points · 2 days ago
The order things move in, since nobody explains it and it worries people.
Postprandial excursions generally respond earliest. Variability tends to narrow before the average does, which is visible on a sensor and invisible on a lab result. Fasting glucose is often the laggard, and A1c — being a three-month average — is the last thing to reflect anything.
So a month in which the sensor looks better and the fasting number has not moved is the ordinary sequence, not a contradiction. Knowing that in advance would have saved me a quarter of unnecessary worry, which is why it is worth writing down.
comment on [PCOS] my androgens moved before my weight did and nobody had mentioned that was possible in c/glp1women · 267 points · 3 days ago
Your ordering is not surprising if you think of insulin as the mediator rather than weight. Insulin sensitivity improves early — well before meaningful fat loss — and hyperinsulinaemia is a direct driver of ovarian androgen production and of SHBG suppression.
So "weight loss improved my PCOS" may be the wrong causal story in a lot of cases. "Improved insulin signalling improved both" fits the timelines better.
HOMA-IR is crude and free. If you have fasting insulin and glucose from month zero you can check whether that fits your own data.
comment on what is bac water and why does everyone keep saying it in c/newbiequestions · 14 points · 5 days ago
Not quite.
Agreed, and for anyone finding this later: that is the normal experience, not a warning sign.
comment on [Results] came off insulin entirely and i still check twice a day in c/t2dglp1 · 3 points · 6 days ago
hypoglycaemia risk depends far more on what else you take
comment on [Log] public log, started week 1, currently week 90, still updating in c/dosinglogs · 1 points · 6 days ago
log what you did, not what you meant to do
comment on [Results] came off insulin entirely and i still check twice a day in c/t2dglp1 · 3 points · 6 days ago
Identifying details redacted from the exported report above.
comment on [Speculation] what happens to the research-peptide supply chain if this lands in c/orforglipron · -15 points · 6 days ago
daily dosing changes adherence in both directions
comment on [Discussion] the Ontario answer is not the Alberta answer in c/glp1canada · 21 points · 8 days ago
Kept every form and reference number. When they had no record of a submission, I did.
comment on [Update] week 12 — the honest version, including the two missed doses in c/dosinglogs · 80 points · 12 days ago
Disagree with daily weighing. You are logging fluid, and the emotional cost is real for very little information.
comment on the glycaemic control thing finally clicked for me and I want to write it down in c/t2dglp1 · 7 points · 19 days ago
Identifying details redacted from the exported report above.
comment on why does nobody talk about province in c/glp1canada · 22 points · 19 days ago
Special authorization is a documented exception process with published criteria. Applications that answer those criteria explicitly, point by point, fare better than general clinical narratives.
comment on help me understand oral GLP-1, I have read the wiki twice in c/orforglipron · 18 points · 1 months ago
Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.
comment on unpopular opinion: most of what gets said here about log is guesswork in c/dosinglogs · 39 points · 1 months ago
I would not draw a trend line through that.
Agreed — and the payoff genuinely arrives in month six, not week two.
comment on why does nobody talk about A1c in c/t2dglp1 · 57 points · 1 months ago
Retitled — the original quoted an obesity endpoint as a glycaemic one.
comment on Canada is the most under-discussed thing on this board in c/glp1canada · 30 points · 1 months ago
Quantity limits restrict how much may be dispensed in a period even where coverage exists. They are a distinct barrier and require a distinct request.
comment on help me understand T2D, I have read the wiki twice in c/t2dglp1 · 70 points · 2 months ago
Push back: one sensor reading is not a data point worth acting on, especially in the first day of wear.
Agreed, and the glucose-dependence point is the reason the risk profile reads the way it does.
comment on [Results] 78 weeks, 16kg, and beginner was the hard part in c/newbiequestions · 2 points · 2 months ago
Careful — that is a dosing recommendation dressed as an anecdote, and this board removes those.
comment on someone explain glycaemic control to me like I have not read a paper in years in c/t2dglp1 · 91 points · 2 months ago
The order things move in, since nobody explains it and it worries people.
Postprandial excursions generally respond earliest. Variability tends to narrow before the average does, which is visible on a sensor and invisible on a lab result. Fasting glucose is often the laggard, and A1c — being a three-month average — is the last thing to reflect anything.
So a month in which the sensor looks better and the fasting number has not moved is the ordinary sequence, not a contradiction. Knowing that in advance would have saved me a quarter of unnecessary worry, which is why it is worth writing down.
comment on someone explain metformin to me like I have not read a paper in years in c/t2dglp1 · 8 points · 3 months ago
Retitled — the original quoted an obesity endpoint as a glycaemic one.
comment on ACHIEVE: what the trials say vs what this community says in c/orforglipron · 5 points · 3 months ago
This. The absence of food and water timing restrictions is the practical difference people will actually notice.
comment on anyone else notice T2D kicking in around week 89 in c/t2dglp1 · 9 points · 3 months ago
Left up. It distinguishes the sensor data from the lab result, which most posts here do not.
comment on anyone else notice what is kicking in around week 47 in c/newbiequestions · 7 points · 3 months ago
This. Ask the basic question; the answers are what make the board searchable for the next person.
comment on anyone else notice what is kicking in around week 47 in c/newbiequestions · 38 points · 3 months ago
That is area percent from a certificate, not the amount of peptide in the vial. Two different numbers and a very common mix-up.
comment on week 66 check-in — 26kg down, fatigue manageable, one thing confusing me in c/orforglipron · 11 points · 3 months ago
Agreed, and it is why the oral peptide comparison keeps misleading people.
mateusz_mensah is right that milligram comparisons across classes tell you nothing.
comment on switched from 2.5mg to 15mg and muscle cramps got better, not worse in c/dosinglogs · 57 points · 4 months ago
That template is elaborate enough that you will stop using it by week ten. Mine was.
comment on [Question] how do you actually verify glycaemic control in c/t2dglp1 · 37 points · 5 months ago
sensor accuracy varies and the first day of a sensor is the worst
comment on basics — my 18-week log, condensed into one table in c/newbiequestions · 48 points · 5 months ago
I confused two very similar words on my first order and asked here, expecting to be mocked. Three people explained it properly instead.
comment on New Zealand: Canada, and what it actually costs here in c/glp1canada · 10 points · 5 months ago
Health Canada approval is not coverage
comment on New Zealand: Canada, and what it actually costs here in c/glp1canada · 17 points · 5 months ago
Have you asked the pharmacist to check?
comment on New Zealand: Canada, and what it actually costs here in c/glp1canada · 24 points · 5 months ago
What did the denial actually say?
comment on tried week one for 18 weeks. here is what happened. in c/newbiequestions · 1 points · 6 months ago
Small correction, said kindly: those are two different products with similar names, and the difference matters for a multi-draw vial.
comment on [Question] non-peptide — what am I missing here in c/orforglipron · 1 points · 7 months ago
Which programme and which readout are you quoting?
comment on reading waist threads from 2024 and half of it aged badly in c/dosinglogs · 5 points · 7 months ago
Annotated the fortnight I changed training. Without that note the numbers around it would look like a mystery.
comment on [Results] 69 weeks, 14kg, and T2D was the hard part in c/t2dglp1 · 124 points · 8 months ago
Pointing this at whoever manages your diabetes. We compare experiences here; we do not adjust regimens.
comment on 6 months in and weight is still the thing I get wrong in c/dosinglogs · 8 points · 8 months ago
Reconstructed six weeks from memory once and later found receipts that contradicted my own log.
intent_to_treat is right about blanks. Silent gaps make the series lie.
comment on [Discussion] first time is doing more work than we give it credit for in c/newbiequestions · 2 points · 8 months ago
ask the dumb question, three other people are searching for it
comment on A1c: the version I wish someone had shown me in week 1 in c/t2dglp1 · 14 points · 9 months ago
Left up. It distinguishes the sensor data from the lab result, which most posts here do not.
comment on the CGM question that gets asked weekly, answered properly in c/t2dglp1 · 15 points · 9 months ago
Identifying details redacted from the exported report above.