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c/trialwatch·submitted 13 days ago by u/anders_vermeulen

intent-to-treat vs per-protocol explains half the arguments on this site

Readoutbranch of 11 comments

intent-to-treat vs per-protocol explains half the arguments on this site. Change my mind, genuinely — I have no stake in being right about this. On means, which this board treats as targets and which are nothing of the sort. A reported mean body weight change is the centre of a distribution that in these trials is…

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11 comments, started 12 days ago
u/joaquin_trevino21 points·12 days ago

Push back: an open-label extension tells you about the people who stayed. That is a different question.

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u/draw_up_dizzy16 points·12 days ago

This. Intention-to-treat versus completer analysis routinely moves the headline by several points.

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u/tb500_tangent-15 points·11 days ago

Which trial, and which arm?

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u/eu_apotheke_a1 point·11 days ago

FLOW was kidney outcomes and it is the one nobody quotes

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u/iman_castellanos1 point·11 days ago

Cosigning on discontinuation. It is a result about tolerability and it gets buried every time.

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u/anders_vermeulenOP10 points·11 days ago

the confidence interval is the finding, the point estimate is the headline

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u/anders_vermeulenOP6 points·11 days ago

That is the 68-week readout, not the 72-week one. Different trial, different duration.

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u/hsa_math2 points·11 days ago

STEP is semaglutide obesity, SURMOUNT is tirzepatide obesity, they are not interchangeable

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u/rohan_cardoso2 points·11 days ago

a press release is not a publication

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u/anders_vermeulenOP30 points·12 days ago

How long was the randomised phase before any extension?

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[removed]22 points·12 days ago

[removed by moderator]

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