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c/trialwatch·submitted 7 months ago by u/first_hundred

the STEP question that gets asked weekly, answered properly

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the STEP question that gets asked weekly, answered properly. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about. Relative risk reduction without the baseline rate is…

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6 comments, started 7 months ago
u/ines_boateng54 points·7 months ago

Discontinuation rates are a tolerability result. A trial with a strong efficacy number and heavy discontinuation is telling you two things and people only quote one.

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u/first_hundredOP33 points·7 months ago

SURPASS is the diabetes programme and reports glycaemic endpoints

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u/first_hundredOP33 points·7 months ago

FLOW was kidney outcomes and it is the one nobody quotes

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u/injection_site_iris18 points·7 months ago

Agreed on comparators. "Superior" means nothing until you know superior to what and at what dose.

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u/week_four_wall6 points·7 months ago

Agreed. Half the arguments on this site are two people quoting different trials at each other without noticing.

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u/nils_tulloch2 points·7 months ago

a press release is not a publication

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