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c/tirzepatide·submitted 1 year ago by u/ignacio_vanhecke

[Results] 47 weeks, 15kg, and GIP was the hard part

Resultsbranch of 7 comments

47 weeks, 15kg, and GIP was the hard part. Same spreadsheet I have been keeping since the start, nothing retrofitted. Since the title puts numbers in the shop window: 47 weeks and 15kg. Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working. The…

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7 comments, started 1 year ago
u/tidy_vialdrawer_pls40 points·1 year ago

Switching from semaglutide, since three people asked in this thread alone.

There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.

None of that is a recommendation. It is what the threads say, and the threads are not a clinic.

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u/hana_pereira28 points·1 year ago

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

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u/hugo_bergstrom20 points·1 year ago

21kg over 82 weeks, never went past 10mg, and food noise stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/georgi_chowdhury15 points·1 year ago

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

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u/priya_guerrero9 points·1 year ago

Pen or vial? The step sizes available differ and it changes this answer.

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u/throwaway_titration8 points·1 year ago·edited

Came off sema and onto tirz with a two-week gap.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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