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c/tirzepatide·submitted 1 year ago by u/kaia_wojcik

how much of what we believe about dual agonist actually comes from GIP threads

Side Effectsbranch of 7 comments

The title is the whole question — how much of what we believe about dual agonist actually comes from GIP threads — but here is why I am asking. The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the…

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7 comments, started 1 year ago
u/mikkel_ogunleye71 points·1 year ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/incretin_ivypharmacology16 points·1 year ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/forest_plot_fionastats13 points·1 year ago

hold the dose that works, the ladder is not a leaderboard

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u/hugo_bergstrom6 points·1 year ago·edited

hold the dose that works, the ladder is not a leaderboard

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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u/marta_dziedzic8 points·1 year ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/mikkel_kimani4 points·1 year ago

2.5 is the starter dose and it is not meant to be the dose that works

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u/amara_halonen10 points·1 year ago·edited

stepping every four weeks is a ceiling on speed, not a schedule you must hit

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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