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c/tirzepatide·submitted 1 year ago by u/santiago_villalobos

why does nobody talk about Zepbound

Discussionbranch of 7 comments

Asking properly rather than in a comment on somebody else’s thread: why does nobody talk about Zepbound. Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate. Held 7.5 for five months. Everyone kept…

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7 comments, started 1 year ago
u/signe_villalobos1k points·1 year ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/discount_math_dm645 points·1 year ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/teodor_szabo224 points·1 year ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/santiago_villalobos179 points·1 year ago

2.5 is the starter dose and it is not meant to be the dose that works

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u/elin_varga93 points·1 year ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/zaid_balogun71 points·1 year ago

What step are you on and how long have you been there?

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u/ignacio_vanhecke869 points·1 year ago

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

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