[Discussion] we are measuring tirzepatide at the wrong time and calling it noise
we are measuring tirzepatide at the wrong time and calling it noise. Change my mind, genuinely — I have no stake in being right about this. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled. Came off sema and onto tirz with a two-week gap. The…
Not sure that follows. You went up a step and changed your training in the same fortnight.
Not sure that follows.
Saving this one. It is the clearest statement of the stall problem I have read here.
Not sure that follows.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
the reflux profile is genuinely gentler than people expect coming from sema
the reflux profile is genuinely gentler than people expect coming from sema
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
Careful with "everyone tolerates it better".
santiago_villalobos is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
2.5 is the starter dose and it is not meant to be the dose that works
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.